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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730832
Species: Homo sapiens
RGD Object: Gene
Symbol: BMP4
Name: bone morphogenetic protein 4
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BMP4affects expressionEXP 6480464CTDEstradiol affects the expression of BMP4 mRNAPMID:14699072 PMID:22574217
BMP4decreases expressionEXP 6480464CTDEstradiol results in decreased expression of BMP4 mRNAPMID:26921789
BMP4increases expressionEXP 6480464CTDEstradiol results in increased expression of BMP4 mRNAPMID:31646340
BMP4multiple interactionsEXP 6480464CTD[Estradiol binds to ESR2 protein] which results in increased expression of BMP4 mRNAPMID:20404318
BMP4decreases expressionISOBmp4 (Mus musculus)6480464CTDEstradiol results in decreased expression of BMP4 mRNAPMID:23144751
BMP4multiple interactionsISOBmp4 (Rattus norvegicus)6480464CTD[BMP4 protein results in increased expression of CYP19A1 mRNA] promotes the reaction [FSHB protein results in increased abundance of Estradiol]; BMP4 protein inhibits the reaction [IGF1 protein promotes the reaction [FSHB protein results in increased abundance of Estradiol]]PMID:22067323
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