GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esrra | affects expression | ISO | ESRRA (Homo sapiens) | 6480464 | CTD | Estradiol affects the expression of ESRRA mRNA | PMID:22574217 | Esrra | decreases expression | ISO | Esrra (Rattus norvegicus) | 6480464 | CTD | Estradiol results in decreased expression of ESRRA mRNA | PMID:15458797 | Esrra | decreases expression | ISO | ESRRA (Homo sapiens) | 6480464 | CTD | Estradiol results in decreased expression of ESRRA mRNA | PMID:15968320 | Esrra | increases expression | ISO | Esrra (Rattus norvegicus) | 6480464 | CTD | Estradiol results in increased expression of ESRRA mRNA | PMID:12193582 PMID:15458797 | Esrra | increases expression | ISO | ESRRA (Homo sapiens) | 6480464 | CTD | Estradiol results in increased expression of ESRRA mRNA; Estradiol results in increased expression of ESRRA protein | PMID:15223131 PMID:20211987 PMID:23019147 PMID:31614463 PMID:32030086 | Esrra | multiple interactions | ISO | ESRRA (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of ESRRA mRNA]; [Estradiol co-treated with TGFB1 protein] results in decreased expression of ESRRA mRNA; Dinoprostone promotes the reaction [ESRRA protein promotes the reaction [Testosterone results in increased abundance of Estradiol]]; ESRRA protein promotes the reaction [Testosterone results in increased abundance of Estradiol]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of ESRRA mRNA]; GPER1 protein promotes the reaction [Estradiol results in increased expression of ESRRA mRNA]; Pertussis Toxin inhibits the reaction [Estradiol results in increased expression of ESRRA mRNA] | PMID:15968320 PMID:20211987 PMID:20351196 PMID:30165855 | |
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