GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | ABCB1 | decreases expression | EXP | | 6480464 | CTD | Estradiol results in decreased expression of ABCB1 mRNA | PMID:24758408 | ABCB1 | increases expression | EXP | | 6480464 | CTD | Estradiol results in increased expression of ABCB1 mRNA; Estradiol results in increased expression of ABCB1 protein | PMID:15290871 PMID:19580841 PMID:19813763 PMID:20106945 | ABCB1 | multiple interactions | EXP | | 6480464 | CTD | [Estradiol results in decreased expression of ABCB1 protein] which results in increased uptake of and results in increased susceptibility to Vincristine; Dactinomycin inhibits the reaction [Estradiol results in increased expression of ABCB1 mRNA]; Dactinomycin inhibits the reaction [Estradiol results in increased expression of ABCB1 protein]; EGF protein promotes the reaction [Estradiol results in decreased expression of ABCB1 mRNA]; ESR1 protein affects the reaction [Estradiol results in decreased expression of ABCB1 protein]; Tamoxifen inhibits the reaction [Estradiol results in decreased expression of ABCB1 protein] | PMID:16925584 PMID:19813763 PMID:24758408 | ABCB1 | decreases expression | ISO | Abcb1a (Mus musculus) | 6480464 | CTD | Estradiol results in decreased expression of ABCB1A mRNA | PMID:14664709 | ABCB1 | decreases expression | ISO | Abcb1a (Rattus norvegicus) | 6480464 | CTD | Estradiol results in decreased expression of ABCB1A mRNA | PMID:26945725 | | ||||||||||||||||||||||
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