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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 728891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gjb2
Name: gap junction protein, beta 2
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gjb2affects expressionEXP 6480464CTDEstradiol affects the expression of GJB2 mRNAPMID:32145629
Gjb2increases expressionEXP 6480464CTDEstradiol results in increased expression of GJB2 mRNAPMID:26945725
Gjb2multiple interactionsEXP 6480464CTD[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of GJB2 mRNA; [Estradiol co-treated with Plant Preparations] results in increased expression of GJB2 mRNAPMID:26945725 PMID:32741896
Gjb2affects expressionISOGjb2 (Mus musculus)6480464CTDEstradiol affects the expression of GJB2 mRNAPMID:15598610
Gjb2increases expressionISOGJB2 (Homo sapiens)6480464CTDEstradiol results in increased expression of GJB2 mRNAPMID:31614463
Gjb2increases expressionISOGjb2 (Mus musculus)6480464CTDEstradiol results in increased expression of GJB2 mRNAPMID:12370124 PMID:15289156 PMID:23144751
Gjb2multiple interactionsISOGJB2 (Homo sapiens)6480464CTD[Estradiol co-treated with Progesterone] results in increased expression of GJB2 mRNA; [Estradiol co-treated with TGFB1 protein] results in decreased expression of GJB2 mRNAPMID:20660070 PMID:30165855
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