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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70921
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col5a2
Name: collagen type V alpha 2 chain
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col5a2affects expressionISOCOL5A2 (Homo sapiens)6480464CTDEstradiol affects the expression of COL5A2 mRNAPMID:22574217
Col5a2increases expressionISOCOL5A2 (Homo sapiens)6480464CTDEstradiol results in increased expression of COL5A2 mRNAPMID:19619570
Col5a2increases expressionISOCol5a2 (Mus musculus)6480464CTDEstradiol results in increased expression of COL5A2 mRNAPMID:19484750
Col5a2multiple interactionsISOCOL5A2 (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of COL5A2 mRNA; [Estradiol co-treated with TGFB1 protein] results in increased expression of COL5A2 mRNAPMID:19619570 PMID:30165855
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