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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69342
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Serpinb5
Name: serpin family B member 5
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:690896480464CTDEstradiol results in increased expression of SERPINB5 mRNA

PMID:19619570, PMID:22609851
increases expressionISORGD:7363476480464CTDEstradiol results in increased expression of SERPINB5 mRNA

PMID:19484750, PMID:25210133
multiple interactionsISORGD:690896480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SERPINB5 mRNA, [Estradiol co-treated with TGFB1 protein] results in increased expression of SERPINB5 mRNA, [Estradiol results in increased activity of ESR1 protein] which results in increased expression of SERPINB5 mRNA, [Progesterone co-treated with Estradiol] results in decreased expression of SERPINB5 mRNA

PMID:17404688, PMID:19619570, PMID:22403704, PMID:30165855
multiple interactionsISORGD:7363476480464CTDESR1 protein promotes the reaction [Estradiol results in increased expression of SERPINB5 mRNA]

PMID:25210133
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.