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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68584
Species: Homo sapiens
RGD Object: Gene
Symbol: KCNH1
Name: potassium voltage-gated channel subfamily H member 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDEstradiol results in increased expression of KCNH1 mRNA

PMID:19351862
multiple interactionsEXP 6480464CTD[Estradiol co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA, [Estradiol co-treated with fulvestrant co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA, [Estradiol co-treated with Tamoxifen co-treated with ESR1 protein] results in increased expression of KCNH1 mRNA, fulvestrant inhibits the reaction [Estradiol results in increased expression of KCNH1 mRNA]

PMID:19351862
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.