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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDEstradiol results in increased expression of CCND1 mRNA, Estradiol results in increased expression of CCND1 protein

PMID:21980073, PMID:24236210
multiple interactionsEXP 6480464CTD[Methylnitrosourea co-treated with Estradiol] results in increased expression of CCND1 mRNA, [Methylnitrosourea co-treated with Estradiol] results in increased expression of CCND1 protein, [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in increased expression of CCND1 mRNA, [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in increased expression of CCND1 protein

PMID:20732338
affects expressionISORGD:685566480464CTDEstradiol affects the expression of CCND1 mRNA

PMID:11896290, PMID:22574217
affects expressionISORGD:685576480464CTDEstradiol affects the expression of CCND1 mRNA

PMID:15598610, PMID:9094091
affects localizationISORGD:685566480464CTDEstradiol affects the localization of CCND1 protein

PMID:16061635
affects localizationISORGD:685576480464CTDEstradiol affects the localization of CCND1 protein

PMID:15845746
decreases expressionISORGD:685566480464CTDEstradiol results in decreased expression of CCND1 mRNA

PMID:29654831
increases expressionISORGD:685566480464CTDEstradiol metabolite results in increased expression of CCND1 mRNA, Estradiol results in increased expression of CCND1, Estradiol results in increased expression of CCND1 mRNA, Estradiol results in increased expression of CCND1 protein

PMID:15297603, PMID:15897899, PMID:15955616, PMID:16839579, PMID:17266178, PMID:18275596, PMID:18556351, PMID:18997820, PMID:19361625, PMID:19496085, PMID:19584281, PMID:19800779, PMID:19838210, PMID:20204298, PMID:20206645, PMID:20208560, PMID:20228224, PMID:20302909, PMID:20372779, PMID:21826169, PMID:22082530, PMID:22113133, PMID:22552626, PMID:23052036, PMID:23094148, PMID:23229410, PMID:23328252, PMID:23524099, PMID:23804311, PMID:23810794, PMID:23933164, PMID:24481588, PMID:24684733, PMID:24758408, PMID:25616260, PMID:26344002, PMID:26865669, PMID:26877835, PMID:27260121, PMID:27366082, PMID:27514991, PMID:27539251, PMID:28215542, PMID:28711546, PMID:29890199, PMID:8927716, PMID:9049186, PMID:9705214
increases expressionISORGD:685576480464CTDEstradiol results in increased expression of CCND1 mRNA, Estradiol results in increased expression of CCND1 protein

PMID:11861973, PMID:17640349, PMID:23684557
multiple interactionsISORGD:685566480464CTD4-fluorobenzoyl-TN-14003 inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA], [Estradiol co-treated with EGF protein] results in increased expression of CCND1 mRNA, [Estradiol co-treated with Medroxyprogesterone Acetate co-treated with Bucladesine co-treated with Decitabine] affects the expression of CCND1 protein, [Estradiol co-treated with Medroxyprogesterone Acetate co-treated with Bucladesine co-treated with Decitabine] results in decreased expression of CCND1 mRNA, [Estradiol co-treated with Medroxyprogesterone Acetate co-treated with Bucladesine] results in decreased expression of CCND1 mRNA, [Estradiol co-treated with Medroxyprogesterone Acetate co-treated with Bucladesine] results in decreased expression of CCND1 protein, [Estradiol co-treated with Progesterone] results in decreased expression of CCND1 mRNA, [Estradiol co-treated with Resveratrol] results in decreased expression of CCND1 mRNA, [Estradiol results in increased activity of ESR1 protein] which results in increased expression of CCND1 mRNA, [Estradiol results in increased expression of CCND1 mRNA] which results in increased susceptibility to Cisplatin, [Estradiol results in increased expression of CCND1 mRNA] which results in increased susceptibility to Doxorubicin, Acetylcysteine inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA], AKT1 protein affects the reaction [Estradiol results in increased expression of CCND1 protein], BRCA1 protein affects the reaction [Estradiol results in increased expression of CCND1 mRNA], Butyrophenones inhibits the reaction [[Estradiol results in increased activity of ESR1 protein] which results in increased expression of CCND1 mRNA], CCND1 protein promotes the reaction [Estradiol results in increased activity of ESR1 protein], Decitabine inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA], Dihydrotestosterone inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA], Dihydrotestosterone inhibits the reaction [Estradiol results in increased expression of CCND1 protein], ESR1 mutant form inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA], ESR1 protein alternative form inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA], Estradiol inhibits the reaction [Fenofibrate results in increased expression of CCND1 protein], Estradiol inhibits the reaction [Fingolimod Hydrochloride results in decreased expression of CCND1 mRNA], Estradiol inhibits the reaction [fludioxonil results in increased expression of CCND1 mRNA], Estradiol promotes the reaction [CDKN1A protein binds to CCND1 protein], Estradiol promotes the reaction [NOTCH1 protein binds to CCND1 promoter], Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [CDKN1A protein binds to CCND1 protein]], Ethidium inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA], Fingolimod Hydrochloride inhibits the reaction [Estradiol results in decreased expression of CCND1 mRNA], Fulvestrant inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA], Fulvestrant inhibits the reaction [Estradiol results in increased expression of CCND1 protein], Genistein inhibits the reaction [Estradiol results in increased expression of CCND1 protein], Genistein inhibits the reaction [Estradiol results in increased expression of CCND1], IGF1R mutant form inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA], JUN mutant form inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA], JUN mutant form inhibits the reaction [Estradiol results in increased expression of CCND1 protein], Resveratrol inhibits the reaction [Estradiol results in increased expression of CCND1 protein], Rotenone inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA], sodium arsenite promotes the reaction [Estradiol results in increased expression of CCND1 mRNA], Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of CCND1 mRNA], Tamoxifen inhibits the reaction [Estradiol results in increased expression of CCND1 mRNA], Tamoxifen inhibits the reaction [Estradiol results in increased expression of CCND1 protein], Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CCND1 protein], U 0126 inhibits the reaction [Estradiol results in increased expression of CCND1 protein]

PMID:15897899, PMID:16328721, PMID:18275596, PMID:18997820, PMID:19361625, PMID:19584281, PMID:19838210, PMID:20206645, PMID:20208560, PMID:20219890, PMID:20228224, PMID:20302909, PMID:20660070, PMID:21041310, PMID:22082530, PMID:22534328, PMID:22552626, PMID:23094148, PMID:23229410, PMID:23328252, PMID:23436777, PMID:23804311, PMID:23810794, PMID:23933164, PMID:24684733, PMID:24758408, PMID:26344002, PMID:26877835, PMID:27260121, PMID:27539251, PMID:28323900, PMID:29134746, PMID:29654831, PMID:29890199, PMID:9705214
multiple interactionsISORGD:685576480464CTD[Estradiol co-treated with Progesterone] results in increased expression of CCND1 mRNA, Estradiol promotes the reaction [ESR1 protein binds to CCND1 promoter], Estradiol promotes the reaction [FOS protein binds to CCND1 promoter], Fulvestrant inhibits the reaction [Estradiol affects the expression of CCND1 mRNA], Lithium Chloride inhibits the reaction [Progesterone inhibits the reaction [Estradiol affects the localization of CCND1 protein]], Progesterone inhibits the reaction [Estradiol affects the localization of CCND1 protein], Tamoxifen inhibits the reaction [Estradiol affects the expression of CCND1 mRNA]

PMID:15845746, PMID:18556351, PMID:23684557, PMID:9094091
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.