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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621399
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Skil
Name: SKI-like proto-oncogene
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13148306480464CTDEstradiol results in increased expression of SKIL mRNA, Estradiol results in increased expression of SKIL protein

PMID:23019147, PMID:24308608, PMID:26407941
increases expressionISORGD:13148316480464CTDEstradiol results in increased expression of SKIL mRNA

PMID:25210133
multiple interactionsISORGD:13148306480464CTD[Estradiol co-treated with TGFB1 protein] results in increased expression of SKIL mRNA, Fulvestrant inhibits the reaction [Estradiol results in increased expression of SKIL protein], Genistein inhibits the reaction [Estradiol results in increased expression of SKIL protein]

PMID:26407941, PMID:30165855
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.