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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61807
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Foxm1
Name: forkhead box M1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Foxm1decreases expressionEXP 6480464CTDEstradiol results in decreased expression of FOXM1 mRNAPMID:32145629
Foxm1decreases expressionISOFOXM1 (Homo sapiens)6480464CTDEstradiol results in decreased expression of FOXM1 mRNAPMID:31646340
Foxm1increases activityISOFOXM1 (Homo sapiens)6480464CTDEstradiol results in increased activity of FOXM1 proteinPMID:27592001
Foxm1increases expressionISOFOXM1 (Homo sapiens)6480464CTDEstradiol results in increased expression of FOXM1 mRNA; Estradiol results in increased expression of FOXM1 proteinPMID:18310284 PMID:19167446 PMID:20208560 PMID:24424067
Foxm1increases expressionISOFoxm1 (Mus musculus)6480464CTDEstradiol results in increased expression of FOXM1 mRNAPMID:25210133
Foxm1increases response to substanceISOFOXM1 (Homo sapiens)6480464CTDFOXM1 protein results in increased susceptibility to EstradiolPMID:20208560
Foxm1multiple interactionsISOFOXM1 (Homo sapiens)6480464CTDESR1 protein promotes the reaction [Estradiol results in increased expression of FOXM1 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of FOXM1 protein]; Estradiol promotes the reaction [[ESR1 protein binds to FOXM1 promoter] which results in increased expression of FOXM1 mRNA]; Estradiol promotes the reaction [ESR1 protein binds to FOXM1 promoter]; Tamoxifen inhibits the reaction [Estradiol promotes the reaction [[ESR1 protein binds to FOXM1 promoter] which results in increased expression of FOXM1 mRNA]]PMID:20208560
Foxm1multiple interactionsISOFoxm1 (Mus musculus)6480464CTDESR1 protein promotes the reaction [Estradiol results in increased expression of FOXM1 mRNA]PMID:25210133
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