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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3310
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pfkfb4
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pfkfb4multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Estradiol] results in decreased expression of PFKFB4 mRNAPMID:26496021
Pfkfb4decreases expressionISOPFKFB4 (Homo sapiens)6480464CTDEstradiol results in decreased expression of PFKFB4 mRNAPMID:20106945 PMID:21632981
Pfkfb4multiple interactionsISOPFKFB4 (Homo sapiens)6480464CTD[Estradiol co-treated with Norethindrone Acetate] results in increased expression of PFKFB4 mRNA; [Estradiol co-treated with TGFB1 protein] results in increased expression of PFKFB4 mRNAPMID:22217510 PMID:30165855
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