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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2984
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Krt8
Name: keratin 8
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDEstradiol results in decreased expression of KRT8 mRNA

PMID:17522070
multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Estradiol] results in increased expression of KRT8 mRNA

PMID:26496021
decreases expressionISORGD:7355366480464CTDEstradiol results in decreased expression of KRT8 mRNA

PMID:16705744
increases expressionISORGD:7355366480464CTDEstradiol results in increased expression of KRT8 mRNA

PMID:14605097
increases expressionISORGD:7355376480464CTDEstradiol results in increased expression of KRT8 mRNA

PMID:15289156, PMID:19484750
multiple interactionsISORGD:7355366480464CTD[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of KRT8 mRNA, Azacitidine inhibits the reaction [[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of KRT8 mRNA], KRT8 protein promotes the reaction [fulvestrant inhibits the reaction [Estradiol results in increased activity of ESR1 protein]]

PMID:20061804, PMID:20823114
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.