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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2875
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igfbp4
Name: insulin-like growth factor binding protein 4
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igfbp4affects expressionISOIGFBP4 (Homo sapiens)6480464CTDEstradiol affects the expression of IGFBP4 mRNAPMID:14699072
Igfbp4increases expressionISOIgfbp4 (Mus musculus)6480464CTDEstradiol results in increased expression of IGFBP4 mRNAPMID:12469912
Igfbp4increases expressionISOIGFBP4 (Homo sapiens)6480464CTDEstradiol results in increased expression of IGFBP4 mRNAPMID:14605097 PMID:15072547 PMID:15757668 PMID:16474171 PMID:21185374 PMID:21826169 PMID:26683377 PMID:31614463 PMID:31646340
Igfbp4multiple interactionsISOIGFBP4 (Homo sapiens)6480464CTD[Cycloheximide co-treated with Estradiol] results in increased expression of IGFBP4 mRNA; [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of IGFBP4 mRNA; [Estradiol co-treated with Progesterone] results in decreased expression of IGFBP4 mRNA; [Estradiol co-treated with TGFB1 protein] results in increased expression of IGFBP4 mRNA; [Estradiol results in increased activity of ESR1 protein] which results in increased expression of IGFBP4 mRNA; [Estradiol results in increased activity of ESR2 protein] which results in increased expression of IGFBP4 mRNA; Fulvestrant inhibits the reaction [Estradiol results in increased expression of IGFBP4 mRNA]PMID:12399409 PMID:15072547 PMID:20660070 PMID:20823114 PMID:30165855 PMID:31646340
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