GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Htr1a | decreases expression | EXP | | 6480464 | CTD | Estradiol results in decreased expression of HTR1A protein | PMID:22265196 | Htr1a | increases expression | EXP | | 6480464 | CTD | Estradiol results in increased expression of HTR1A mRNA | PMID:22265196 | Htr1a | multiple interactions | EXP | | 6480464 | CTD | [Estradiol co-treated with Sertraline] affects the expression of HTR1A mRNA; Estradiol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of OXT protein modified form]; Estradiol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of POMC protein modified form]; GPER1 protein affects the reaction [Estradiol results in decreased expression of HTR1A protein] | PMID:18650020 PMID:22265196 | Htr1a | multiple interactions | ISO | HTR1A (Homo sapiens) | 6480464 | CTD | [Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of HTR1A mRNA; [Estradiol promotes the reaction [PARP1 protein binds to HTR1A promoter mutant form]] which results in decreased expression of HTR1A mRNA; Estradiol promotes the reaction [PARP1 protein binds to HTR1A promoter mutant form] | PMID:20823114 PMID:21990073 | | ||||||||||||||||||||||
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