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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2545
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Egr3
Name: early growth response 3
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egr3increases expressionISOEGR3 (Homo sapiens)6480464CTDEstradiol results in increased expression of EGR3 mRNAPMID:15159206 PMID:15223131 PMID:15913882 PMID:19619570 PMID:21185374 PMID:24758408 PMID:25321415 PMID:26865669 PMID:28711546 PMID:31614463 PMID:31646340 PMID:33047385 PMID:33111528
Egr3multiple interactionsISOEGR3 (Homo sapiens)6480464CTD[Estradiol co-treated with Progesterone] results in decreased expression of EGR3 mRNA; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of EGR3 mRNA; Arsenic inhibits the reaction [Estradiol results in increased expression of EGR3 mRNA]; EGF protein promotes the reaction [Estradiol results in increased expression of EGR3 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of EGR3 mRNA]; perfluorobutanesulfonic acid inhibits the reaction [Estradiol results in increased expression of EGR3 mRNA]; perfluorobutyric acid inhibits the reaction [Estradiol results in increased expression of EGR3 mRNA]; perfluorohexanesulfonic acid inhibits the reaction [Estradiol results in increased expression of EGR3 mRNA]; perfluorooctane sulfonic acid inhibits the reaction [Estradiol results in increased expression of EGR3 mRNA]; perfluoropentanoic acid inhibits the reaction [Estradiol results in increased expression of EGR3 mRNA]; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of EGR3 mRNA]PMID:19619570 PMID:20660070 PMID:21185374 PMID:24758408 PMID:31646340 PMID:33047385 PMID:33111528
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