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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1affects expressionEXP 6480464CTDEstradiol affects the expression of CYP2E1 mRNAPMID:32145629
Cyp2e1multiple interactionsEXP 6480464CTD[Estradiol co-treated with Plant Preparations] results in decreased expression of CYP2E1 mRNAPMID:26945725
Cyp2e1decreases expressionISOCyp2e1 (Mus musculus)6480464CTDEstradiol results in decreased expression of CYP2E1 mRNAPMID:19484750
Cyp2e1decreases expressionISOCYP2E1 (Homo sapiens)6480464CTDEstradiol results in decreased expression of CYP2E1 mRNAPMID:20106945
Cyp2e1increases activityISOCYP2E1 (Homo sapiens)6480464CTDEstradiol results in increased activity of CYP2E1 proteinPMID:22837389
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