GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bax | decreases expression | EXP | | 6480464 | CTD | Estradiol results in decreased expression of BAX protein | PMID:15964511 | Bax | increases expression | EXP | | 6480464 | CTD | Estradiol results in increased expression of BAX mRNA | PMID:32145629 | Bax | multiple interactions | EXP | | 6480464 | CTD | [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in decreased expression of BAX protein; [Methylnitrosourea co-treated with Estradiol] results in decreased expression of BAX mRNA; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of BAX mRNA; Estradiol inhibits the reaction [Corticosterone results in increased expression of BAX protein]; Estradiol promotes the reaction [Testosterone inhibits the reaction [Corticosterone results in increased expression of BAX protein]]; Testosterone promotes the reaction [Estradiol inhibits the reaction [Corticosterone results in increased expression of BAX protein]] | PMID:20732338 PMID:22465879 PMID:29625166 | Bax | affects expression | ISO | BAX (Homo sapiens) | 6480464 | CTD | Estradiol affects the expression of BAX mRNA | PMID:11896290 | Bax | decreases expression | ISO | BAX (Homo sapiens) | 6480464 | CTD | Estradiol results in decreased expression of BAX mRNA; Estradiol results in decreased expression of BAX protein | PMID:15870704 PMID:18174961 PMID:31016752 PMID:33484789 PMID:34724321 | Bax | increases expression | ISO | Bax (Mus musculus) | 6480464 | CTD | Estradiol results in increased expression of BAX protein | PMID:21882229 | Bax | increases expression | ISO | BAX (Homo sapiens) | 6480464 | CTD | Estradiol analog results in increased expression of BAX mRNA; Estradiol analog results in increased expression of BAX protein; Estradiol results in increased expression of BAX mRNA | PMID:20106945 PMID:24481588 PMID:36460128 | Bax | multiple interactions | ISO | Bax (Mus musculus) | 6480464 | CTD | Estradiol inhibits the reaction [manganese chloride results in increased expression of BAX protein] | PMID:29183790 | Bax | multiple interactions | ISO | BAX (Homo sapiens) | 6480464 | CTD | 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine inhibits the reaction [Estradiol results in decreased expression of BAX protein]; [Fulvestrant co-treated with 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] inhibits the reaction [Estradiol results in decreased expression of BAX protein]; allyl sulfide inhibits the reaction [Estradiol results in decreased expression of BAX protein]; ESR1 protein alternative form promotes the reaction [allyl sulfide inhibits the reaction [Estradiol results in decreased expression of BAX protein]]; ESR1 protein alternative form promotes the reaction [MK 2206 inhibits the reaction [Estradiol results in decreased expression of BAX protein]]; ESR1 protein alternative form promotes the reaction [RTKI cpd inhibits the reaction [Estradiol results in decreased expression of BAX protein]]; Estradiol inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of BAX protein]; Estradiol inhibits the reaction [APP protein results in increased expression of BAX protein]; Estradiol inhibits the reaction [Hexachlorocyclohexane results in decreased expression of BAX protein]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of BAX protein]; Hexachlorocyclohexane inhibits the reaction [Estradiol results in decreased expression of BAX protein]; MK 2206 inhibits the reaction [Estradiol results in decreased expression of BAX protein]; RTKI cpd inhibits the reaction [Estradiol results in decreased expression of BAX protein]; TXNIP protein inhibits the reaction [Estradiol inhibits the reaction [amyloid beta-protein (1-42) results in increased expression of BAX protein]]; TXNIP protein inhibits the reaction [Estradiol inhibits the reaction [APP protein results in increased expression of BAX protein]] | PMID:15870704 PMID:18174961 PMID:33484789 PMID:34318539 PMID:34724321 | |
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