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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1621634
Species: Mus musculus
RGD Object: Gene
Symbol: Bglap
Name: bone gamma carboxyglutamate protein
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bglapdecreases expressionISOBglap (Rattus norvegicus)6480464CTDEstradiol results in decreased expression of BGLAP proteinPMID:15917159 PMID:15979666
Bglapincreases expressionISOBglap (Rattus norvegicus)6480464CTDEstradiol results in increased expression of BGLAP mRNAPMID:16964405
Bglapincreases expressionISOBGLAP (Homo sapiens)6480464CTDEstradiol results in increased expression of BGLAP mRNAPMID:17689939
Bglapmultiple interactionsISOBGLAP (Homo sapiens)6480464CTD[Estradiol co-treated with ESR1 protein] results in increased expression of BGLAP mRNA; [Estradiol co-treated with ESR2 protein] results in increased expression of BGLAP mRNA; fulvestrant inhibits the reaction [Estradiol results in increased expression of BGLAP mRNA]PMID:17689939 PMID:19347870
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