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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1606817
Species: Homo sapiens
RGD Object: Gene
Symbol: CLCF1
Name: cardiotrophin like cytokine factor 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CLCF1increases expressionEXP 6480464CTDEstradiol results in increased expression of CLCF1 mRNAPMID:31614463
CLCF1multiple interactionsEXP 6480464CTD[Estradiol binds to ESR2 protein] which results in decreased expression of CLCF1 mRNA; [Estradiol co-treated with TGFB1 protein] results in increased expression of CLCF1 mRNAPMID:20404318 PMID:30165855
CLCF1decreases expressionISOClcf1 (Rattus norvegicus)6480464CTDEstradiol results in decreased expression of CLCF1 mRNAPMID:32145629
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