GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp2b10 | affects expression | EXP | | 6480464 | CTD | Estradiol affects the expression of CYP2B10 mRNA | PMID:7771797 | Cyp2b10 | increases expression | EXP | | 6480464 | CTD | Estradiol results in increased expression of CYP2B10 mRNA | PMID:11075820 PMID:12948398 PMID:23684557 | Cyp2b10 | multiple interactions | EXP | | 6480464 | CTD | Estradiol promotes the reaction [GADD45B protein binds to CYP2B10 promoter]; Estradiol promotes the reaction [NR1I3 protein binds to CYP2B10 promoter]; Estradiol promotes the reaction [PPARGC1A protein binds to CYP2B10 promoter] | PMID:23684557 | Cyp2b10 | increases expression | ISO | CYP2B6 (Homo sapiens) | 6480464 | CTD | Estradiol results in increased expression of CYP2B6 mRNA | PMID:20079471 PMID:22837389 | Cyp2b10 | multiple interactions | ISO | CYP2B6 (Homo sapiens) | 6480464 | CTD | [Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]; [Progesterone co-treated with Estradiol] inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]; Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]; Estradiol inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]; Estradiol promotes the reaction [[ESR1 protein binds to CYP2B6 promoter] which results in increased expression of CYP2B6 mRNA]; Estradiol promotes the reaction [[NCOA3 protein binds to CYP2B6 promoter] which results in increased expression of CYP2B6 mRNA]; NR1I3 mutant form inhibits the reaction [Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]]; NR1I3 mutant form inhibits the reaction [Estradiol inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]] | PMID:20079471 PMID:21768169 | Cyp2b10 | multiple interactions | ISO | Cyp2b3 (Rattus norvegicus) | 6480464 | CTD | [Estradiol co-treated with Plant Preparations] results in decreased expression of CYP2B3 mRNA | PMID:26945725 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |