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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1553810
Species: Mus musculus
RGD Object: Gene
Symbol: Bmp7
Name: bone morphogenetic protein 7
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDEstradiol results in decreased expression of BMP7 mRNA

PMID:14994273
increases expressionEXP 6480464CTDEstradiol results in increased expression of BMP7 mRNA

PMID:19484750
decreases expressionISORGD:13442346480464CTDEstradiol results in decreased expression of BMP7 mRNA

PMID:14994273, PMID:19167446, PMID:24758408
decreases expressionISORGD:6207436480464CTDEstradiol results in decreased expression of BMP7 mRNA

PMID:15680359
increases expressionISORGD:13442346480464CTDEstradiol results in increased expression of BMP7 mRNA

PMID:19619570
multiple interactionsISORGD:13442346480464CTD[Estradiol co-treated with Progesterone] results in decreased expression of BMP7 mRNA, [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of BMP7 mRNA, BMP7 protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of IGFBP1 mRNA], BMP7 protein inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased secretion of IGFBP1 protein], EGF protein inhibits the reaction [Estradiol results in decreased expression of BMP7 mRNA]

PMID:19619570, PMID:20085912, PMID:24758408
multiple interactionsISORGD:6207436480464CTD[bisphenol A co-treated with Estradiol] results in decreased expression of BMP7 mRNA, [BMP7 protein results in increased expression of CYP19A1 mRNA] promotes the reaction [FSHB protein results in increased abundance of Estradiol], BMP7 protein inhibits the reaction [IGF1 protein promotes the reaction [FSHB protein results in increased abundance of Estradiol]]

PMID:22067323, PMID:26496021
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.