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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550011
Species: Mus musculus
RGD Object: Gene
Symbol: Gli1
Name: GLI-Kruppel family member GLI1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gli1decreases expressionEXP 6480464CTDEstradiol results in decreased expression of GLI1 mRNAPMID:15289156
Gli1multiple interactionsEXP 6480464CTD[Estradiol co-treated with Progesterone] results in increased expression of GLI1 mRNA; Estradiol inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]PMID:20434536 PMID:22958837
Gli1decreases expressionISOGli1 (Rattus norvegicus)6480464CTDEstradiol results in decreased expression of GLI1 mRNAPMID:15328011 PMID:20232216 PMID:26945725
Gli1multiple interactionsISOGLI1 (Homo sapiens)6480464CTD[Estradiol co-treated with TGFB1 protein] results in increased expression of GLI1 mRNA; Estradiol inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]PMID:20434536 PMID:30165855
Gli1multiple interactionsISOGli1 (Rattus norvegicus)6480464CTDEstradiol promotes the reaction [Plant Preparations results in decreased expression of GLI1 mRNA]PMID:26945725
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