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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 14180349
Species: Sus scrofa
RGD Object: Gene
Symbol: NOS3
Name: nitric oxide synthase 3
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS3affects expressionEXP 6480464CTDEstradiol affects the expression of NOS3 mRNAPMID:15653758
NOS3decreases expressionEXP 6480464CTDEstradiol results in decreased expression of NOS3 mRNAPMID:16680078
NOS3increases phosphorylationEXP 6480464CTDEstradiol results in increased phosphorylation of NOS3 proteinPMID:16680078 PMID:17618301
NOS3multiple interactionsEXP 6480464CTDEstradiol results in increased phosphorylation of and results in increased activity of NOS3 protein; Fulvestrant inhibits the reaction [Estradiol results in increased phosphorylation of NOS3 protein]PMID:15967841 PMID:17618301
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