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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352024
Species: Homo sapiens
RGD Object: Gene
Symbol: CXCL10
Name: C-X-C motif chemokine ligand 10
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CXCL10increases expressionEXP 6480464CTDEstradiol results in increased expression of CXCL10 mRNA; Estradiol results in increased expression of CXCL10 proteinPMID:15557169 PMID:31614463
CXCL10multiple interactionsEXP 6480464CTD[Estradiol co-treated with TGFB1 protein] results in decreased expression of CXCL10 mRNA; [Progesterone co-treated with Estradiol] results in increased expression of CXCL10 mRNA; Fulvestrant inhibits the reaction [Estradiol results in increased expression of CXCL10 mRNA]PMID:15557169 PMID:17404688 PMID:30165855
CXCL10increases expressionISOCxcl10 (Rattus norvegicus)6480464CTDEstradiol results in increased expression of CXCL10 mRNAPMID:35192832
CXCL10multiple interactionsISOCxcl10 (Mus musculus)6480464CTDEstradiol inhibits the reaction [Dimethoate results in increased expression of CXCL10 mRNA]; Estradiol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 mRNA]; Estradiol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 protein]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Dimethoate results in increased expression of CXCL10 mRNA]]PMID:19533603 PMID:23943137
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