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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347965
Species: Homo sapiens
RGD Object: Gene
Symbol: TUBB3
Name: tubulin beta 3 class III
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TUBB3increases expressionEXP 6480464CTDEstradiol results in increased expression of TUBB3 mRNA; Estradiol results in increased expression of TUBB3 proteinPMID:19466750 PMID:27271280
TUBB3multiple interactionsEXP 6480464CTD[Estradiol co-treated with TGFB1 protein] results in increased expression of TUBB3 mRNA; Fulvestrant inhibits the reaction [Estradiol results in increased expression of TUBB3 mRNA]; Tamoxifen inhibits the reaction [Estradiol results in increased expression of TUBB3 mRNA]PMID:19466750 PMID:30165855
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