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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1342641
Species: Homo sapiens
RGD Object: Gene
Symbol: FHL1
Name: four and a half LIM domains 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FHL1increases expressionEXP 6480464CTDEstradiol results in increased expression of FHL1 mRNAPMID:19619570 PMID:21185374
FHL1multiple interactionsEXP 6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of FHL1 mRNA; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of FHL1 mRNA]PMID:19619570 PMID:21185374
FHL1decreases expressionISOFhl1 (Mus musculus)6480464CTDEstradiol results in decreased expression of FHL1 mRNAPMID:19484750
FHL1decreases expressionISOFhl1 (Rattus norvegicus)6480464CTDEstradiol results in decreased expression of FHL1 mRNAPMID:20149813 PMID:32145629
FHL1multiple interactionsISOFhl1 (Rattus norvegicus)6480464CTDEstradiol promotes the reaction [[ESR2 protein binds to FHL1 promoter] which results in decreased expression of FHL1 mRNA]; Tamoxifen inhibits the reaction [Estradiol results in decreased expression of FHL1 mRNA]PMID:20149813
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