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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1331867
Species: Mus musculus
RGD Object: Gene
Symbol: Scd2
Name: stearoyl-Coenzyme A desaturase 2
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scd2decreases expressionEXP 6480464CTDEstradiol results in decreased expression of SCD2 mRNAPMID:19484750
Scd2decreases expressionISOSCD (Homo sapiens)6480464CTDEstradiol results in decreased expression of SCD mRNAPMID:15757668
Scd2increases expressionISOSCD (Homo sapiens)6480464CTDEstradiol results in increased expression of SCD mRNAPMID:19167446
Scd2multiple interactionsISOSCD (Homo sapiens)6480464CTD[Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of SCD1 mRNA]; [Progesterone co-treated with Estradiol] inhibits the reaction [Phenobarbital results in decreased expression of SCD1 mRNA]; Estradiol inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of SCD1 mRNA]; Estradiol inhibits the reaction [Phenobarbital results in decreased expression of SCD1 mRNA]PMID:21768169
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