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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318375
Species: Mus musculus
RGD Object: Gene
Symbol: Sirt1
Name: sirtuin 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt1decreases expressionISOSIRT1 (Homo sapiens)6480464CTDEstradiol results in decreased expression of SIRT1 mRNAPMID:32030086
Sirt1multiple interactionsISOSIRT1 (Homo sapiens)6480464CTDEstradiol inhibits the reaction [TNF protein promotes the reaction [SIRT1 protein binds to IL6 promoter]]PMID:24771768
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