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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313957
Species: Homo sapiens
RGD Object: Gene
Symbol: RCOR1
Name: REST corepressor 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RCOR1multiple interactionsEXP 6480464CTDEstradiol inhibits the reaction [TNF protein inhibits the reaction [RCOR1 protein binds to IL6 promoter]]; RCOR1 mutant form inhibits the reaction [Estradiol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]PMID:24771768
RCOR1decreases expressionISORcor1 (Rattus norvegicus)6480464CTDEstradiol results in decreased expression of RCOR1 mRNAPMID:20068009 PMID:32145629
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