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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311313
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mthfd2
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mthfd2increases expressionEXP 6480464CTDEstradiol results in increased expression of MTHFD2 mRNAPMID:32145629
Mthfd2multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Estradiol] results in decreased expression of MTHFD2 mRNAPMID:26496021
Mthfd2multiple interactionsISOMTHFD2 (Homo sapiens)6480464CTD[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of MTHFD2 mRNAPMID:20823114
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