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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309841
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Trem2
Name: triggering receptor expressed on myeloid cells 2
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Trem2increases expressionISOTrem2 (Mus musculus)6480464CTDEstradiol results in increased expression of TREM2 mRNAPMID:19484750
Trem2multiple interactionsISOTREM2 (Homo sapiens)6480464CTD[Estradiol co-treated with TGFB1 protein] results in decreased expression of TREM2 mRNAPMID:30165855
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