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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309438
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map3k7
Name: mitogen activated protein kinase kinase kinase 7
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map3k7multiple interactionsEXP 6480464CTD1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [Estradiol inhibits the reaction [Corticosterone results in increased phosphorylation of MAP3K7 protein]]; Estradiol inhibits the reaction [Corticosterone results in increased phosphorylation of MAP3K7 protein]; Flutamide inhibits the reaction [Estradiol inhibits the reaction [Corticosterone results in increased phosphorylation of MAP3K7 protein]]; Testosterone promotes the reaction [Estradiol inhibits the reaction [Corticosterone results in increased phosphorylation of MAP3K7 protein]]PMID:29625166
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