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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306056
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Helz2
Name: helicase with zinc finger 2
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Helz2multiple interactionsEXP 6480464CTD[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of HELZ2 mRNAPMID:32741896
Helz2decreases expressionISOHELZ2 (Homo sapiens)6480464CTDEstradiol results in decreased expression of HELZ2 mRNAPMID:19167446
Helz2multiple interactionsISOHELZ2 (Homo sapiens)6480464CTDEstradiol affects the reaction [ESR1 protein binds to HELZ2 protein]; Estradiol promotes the reaction [ESR1 protein binds to HELZ2 protein]PMID:29389661 PMID:32088792
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