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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305269
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Limch1
Name: LIM and calponin homology domains 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Limch1decreases expressionISOLIMCH1 (Homo sapiens)6480464CTDEstradiol results in decreased expression of LIMCH1 mRNAPMID:19167446
Limch1increases expressionISOLIMCH1 (Homo sapiens)6480464CTDEstradiol results in increased expression of LIMCH1 mRNAPMID:19619570 PMID:21185374
Limch1multiple interactionsISOLIMCH1 (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LIMCH1 mRNA; [Estradiol co-treated with TGFB1 protein] results in decreased expression of LIMCH1 mRNA; Raloxifene Hydrochloride promotes the reaction [Estradiol results in increased expression of LIMCH1 mRNA]PMID:19619570 PMID:21185374 PMID:30165855
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