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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305137
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Med25
Name: mediator complex subunit 25
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Med25multiple interactionsISOMED25 (Homo sapiens)6480464CTD[ESR1 protein co-treated with MED25 protein co-treated with Estradiol] results in increased activity of CYP2C9 protein; [ESR1 protein co-treated with MED25 protein co-treated with Estradiol] results in increased expression of CYP2C9 mRNA; Estradiol promotes the reaction [MED25 protein binds to ESR1 protein]PMID:27273787
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