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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303336
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dnmt3a
Name: DNA methyltransferase 3 alpha
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt3amultiple interactionsEXP 6480464CTD[Testosterone co-treated with Estradiol] affects the reaction [bisphenol A results in increased expression of DNMT3A mRNA]; [Testosterone co-treated with Estradiol] affects the reaction [estradiol-17 beta-benzoate results in increased expression of DNMT3A mRNA]PMID:22109888
Dnmt3adecreases expressionISODNMT3A (Homo sapiens)6480464CTDEstradiol results in decreased expression of DNMT3A mRNAPMID:22952798
Dnmt3aincreases expressionISODNMT3A (Homo sapiens)6480464CTDEstradiol results in increased expression of DNMT3A mRNAPMID:30684530
Dnmt3amultiple interactionsISODNMT3A (Homo sapiens)6480464CTDEstradiol inhibits the reaction [sodium arsenite results in decreased expression of DNMT3A mRNA]; sodium arsenite inhibits the reaction [Estradiol results in decreased expression of DNMT3A mRNA]PMID:22952798
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