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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303246
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dek
Name: DEK proto-oncogene
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13490756480464CTDEstradiol results in increased expression of DEK mRNA, Estradiol results in increased expression of DEK protein

PMID:23071688
increases response to substanceISORGD:13490756480464CTDDEK protein results in increased susceptibility to Estradiol

PMID:23071688
multiple interactionsISORGD:13490756480464CTD1, 3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [Estradiol results in increased expression of DEK protein], Estradiol promotes the reaction [ESR1 protein binds to DEK promoter], Estradiol promotes the reaction [MYC protein binds to DEK promoter], fulvestrant inhibits the reaction [Estradiol results in increased expression of DEK protein]

PMID:23071688
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.