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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11476
Species: Mus musculus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase 1 family, polypeptide A1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:39356480464CTDEstradiol affects the expression of UGT1A1 mRNA

PMID:22389237, PMID:24777823
decreases activityISORGD:13500186480464CTDEstradiol results in decreased activity of UGT1A1 protein

PMID:15378558
decreases expressionISORGD:13500186480464CTDEstradiol results in decreased expression of UGT1A1 mRNA

PMID:15072547, PMID:17982697
decreases glucuronidationISORGD:13500186480464CTDUGT1A1 gene mutant form results in decreased glucuronidation of Estradiol analog

PMID:17898154
increases glucuronidationISORGD:13500186480464CTDUGT1A1 protein results in increased glucuronidation of Estradiol, UGT1A1 protein results in increased glucuronidation of Estradiol analog

PMID:15117964, PMID:15472229, PMID:15593333, PMID:15769885, PMID:16051636, PMID:17898154, PMID:25393417, PMID:27676153, PMID:30237061, PMID:30776358, PMID:31128210
increases glucuronidationISORGD:39356480464CTDUGT1A1 protein results in increased glucuronidation of Estradiol

PMID:31128210
multiple interactionsISORGD:13500186480464CTD[Cycloheximide co-treated with Estradiol] results in decreased expression of UGT1A1 mRNA, [Estradiol co-treated with TGFB1 protein] results in decreased expression of UGT1A1 mRNA, [Warfarin binds to and results in decreased activity of UGT1A1 protein] which results in decreased glucuronidation of Estradiol, Estradiol promotes the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone], Fusidic Acid inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol], shikonin inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol], Warfarin inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol]

PMID:15072547, PMID:15378558, PMID:25393417, PMID:27676153, PMID:30165855, PMID:31128210
multiple interactionsISORGD:39356480464CTD[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of UGT1A1 mRNA], [bisphenol A co-treated with Estradiol] results in increased expression of UGT1A1 mRNA, [Progesterone co-treated with Estradiol] affects the expression of UGT1A1 mRNA, shikonin inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Estradiol]

PMID:22389237, PMID:24777823, PMID:26496021, PMID:31128210
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.