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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11217
Species: Mus musculus
RGD Object: Gene
Symbol: Rarb
Name: retinoic acid receptor, beta
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rarbdecreases expressionISORARB (Homo sapiens)6480464CTDEstradiol results in decreased expression of RARB mRNAPMID:23436777
Rarbmultiple interactionsISORARB (Homo sapiens)6480464CTD[Estradiol results in increased expression of RARB mRNA] which results in increased susceptibility to Cisplatin; [Estradiol results in increased expression of RARB mRNA] which results in increased susceptibility to Doxorubicin; Estradiol promotes the reaction [decitabine results in increased expression of RARB mRNA]; N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide promotes the reaction [Estradiol results in decreased expression of RARB mRNA]PMID:22082530 PMID:23436777 PMID:28323900
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