GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Alox15 | decreases activity | ISO | ALOX15 (Homo sapiens) | 6480464 | CTD | caffeic acid results in decreased activity of ALOX15 protein | PMID:11406566 | Alox15 | multiple interactions | ISO | ALOX15 (Homo sapiens) | 6480464 | CTD | [caffeic acid results in decreased activity of ALOX15 protein] inhibits the reaction [vorinostat results in increased activity of CASP3 protein]; [caffeic acid results in decreased activity of ALOX15 protein] which results in decreased chemical synthesis of 13-hydroxy-9,11-octadecadienoic acid; [caffeic acid results in decreased activity of ALOX15 protein] which results in increased abundance of 13-hydroxy-9,11-octadecadienoic acid; caffeic acid inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased activity of ALOX15 protein] | PMID:10904086 PMID:11406566 PMID:15574791 | | ||||||||||||||||||||||
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