GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ar | multiple interactions | EXP | | 6480464 | CTD | Androstenedione binds to and results in increased activity of AR protein | PMID:28973534 | Ar | affects binding | ISO | Ar (Rattus norvegicus) | 6480464 | CTD | Androstenedione binds to AR protein | PMID:14565775 PMID:19833195 | Ar | multiple interactions | ISO | Ar (Rattus norvegicus) | 6480464 | CTD | AR mutant form inhibits the reaction [Androstenedione results in increased expression of NR5A2 mRNA] | PMID:21273442 | Ar | multiple interactions | ISO | AR (Homo sapiens) | 6480464 | CTD | Androstenedione binds to and affects the activity of AR protein; Androstenedione binds to and results in increased activity of AR protein; Androstenedione inhibits the reaction [[Dihydrotestosterone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein]; NCOA2 protein promotes the reaction [Androstenedione binds to and results in increased activity of AR protein] | PMID:12730620 PMID:15336702 PMID:17804755 PMID:23562765 PMID:33049310 | |
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