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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10187
Species: Mus musculus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:16422
Term: androst-4-ene-3,17-dione
Definition: A 3-oxo Delta(4)-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17. It is a steroid hormone synthesized in the adrenal glands and gonads.
Chemical ID: MESH:D000735
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Armultiple interactionsEXP 6480464CTDAndrostenedione binds to and results in increased activity of AR proteinPMID:28973534
Araffects bindingISOAr (Rattus norvegicus)6480464CTDAndrostenedione binds to AR proteinPMID:14565775 PMID:19833195
Armultiple interactionsISOAr (Rattus norvegicus)6480464CTDAR mutant form inhibits the reaction [Androstenedione results in increased expression of NR5A2 mRNA]PMID:21273442
Armultiple interactionsISOAR (Homo sapiens)6480464CTDAndrostenedione binds to and affects the activity of AR protein; Androstenedione binds to and results in increased activity of AR protein; Androstenedione inhibits the reaction [[Dihydrotestosterone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein]; NCOA2 protein promotes the reaction [Androstenedione binds to and results in increased activity of AR protein]PMID:12730620 PMID:15336702 PMID:17804755 PMID:23562765 PMID:33049310
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