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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69168
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARG
Name: peroxisome proliferator activated receptor gamma
Acc ID: CHEBI:164200
Term: triclosan
Definition: An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes.
Chemical ID: MESH:D014260
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARGaffects bindingEXP 6480464CTDTriclosan binds to PPARG proteinPMID:25314719
PPARGaffects expressionEXP 6480464CTDTriclosan affects the expression of PPARG mRNAPMID:31714634
PPARGincreases expressionEXP 6480464CTDTriclosan results in increased expression of PPARG mRNAPMID:30510588
PPARGmultiple interactionsEXP 6480464CTDTriclosan binds to and results in increased activity of PPARG proteinPMID:33049310
PPARGdecreases expressionISOPparg (Mus musculus)6480464CTDTriclosan results in decreased expression of PPARG mRNA; Triclosan results in decreased expression of PPARG proteinPMID:15707987 PMID:28973666
PPARGincreases expressionISOPparg (Mus musculus)6480464CTDTriclosan results in increased expression of PPARG proteinPMID:33722737
PPARGmultiple interactionsISOPparg (Mus musculus)6480464CTD[Rosiglitazone results in increased activity of PPARG protein] inhibits the reaction [Triclosan results in decreased phosphorylation of AKT1 protein]; beta-Naphthoflavone inhibits the reaction [Triclosan results in increased expression of PPARG protein]; Thyroxine inhibits the reaction [Triclosan results in decreased expression of PPARG protein]; Triclosan binds to and results in increased activity of PPARG proteinPMID:28973666 PMID:33049310 PMID:33722737
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