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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737367
Species: Homo sapiens
RGD Object: Gene
Symbol: NOTCH1
Name: notch receptor 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOTCH1increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of NOTCH1 proteinPMID:35385713
NOTCH1multiple interactionsEXP 6480464CTDITCH protein inhibits the reaction [Lipopolysaccharides results in increased expression of NOTCH1 protein]; JAG1 protein affects the reaction [Lipopolysaccharides results in increased expression of NOTCH1 protein]; JAG1 protein inhibits the reaction [ITCH protein inhibits the reaction [Lipopolysaccharides results in increased expression of NOTCH1 protein]]PMID:35385713
NOTCH1increases expressionISONotch1 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of NOTCH1 proteinPMID:18449946
NOTCH1increases expressionISONotch1 (Rattus norvegicus)6480464CTDLipopolysaccharides results in increased expression of NOTCH1 mRNA; Lipopolysaccharides results in increased expression of NOTCH1 proteinPMID:18449946
NOTCH1multiple interactionsISONotch1 (Mus musculus)6480464CTDNOTCH1 protein affects the reaction [Lipopolysaccharides results in increased expression of CSF1 mRNA]; NOTCH1 protein affects the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; NOTCH1 protein affects the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; NOTCH1 protein affects the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; NOTCH1 protein affects the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; NOTCH1 protein affects the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; NOTCH1 protein affects the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]PMID:18449946
NOTCH1multiple interactionsISONotch1 (Rattus norvegicus)6480464CTDDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of NOTCH1 mRNA]PMID:18449946
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