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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736728
Species: Homo sapiens
RGD Object: Gene
Symbol: SFTPC
Name: surfactant protein C
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SFTPCdecreases expressionISOSftpc (Rattus norvegicus)6480464CTDLipopolysaccharides results in decreased expression of SFTPC proteinPMID:28070109
SFTPCdecreases expressionISOSftpc (Mus musculus)6480464CTDLipopolysaccharides results in decreased expression of SFTPC mRNAPMID:21724861
SFTPCincreases expressionISOSftpc (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of SFTPC proteinPMID:21724861
SFTPCmultiple interactionsISOSftpc (Rattus norvegicus)6480464CTDProtein Kinase Inhibitors inhibits the reaction [Lipopolysaccharides results in decreased expression of SFTPC protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of SFTPC protein]PMID:28070109
SFTPCmultiple interactionsISOSftpc (Mus musculus)6480464CTDERBB4 protein affects the reaction [Lipopolysaccharides results in decreased expression of SFTPC mRNA]; ERBB4 protein affects the reaction [Lipopolysaccharides results in increased expression of SFTPC protein]PMID:21724861
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