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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735707
Species: Homo sapiens
RGD Object: Gene
Symbol: IL1A
Name: interleukin 1 alpha
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL1Adecreases expressionEXP 6480464CTDLipopolysaccharides results in decreased expression of IL1A mRNAPMID:28964808
IL1Aincreases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of IL1A mRNA; Lipopolysaccharides results in increased expression of IL1A proteinPMID:10866999 PMID:15860229 PMID:17929310 PMID:19428942 PMID:21045076 PMID:21135123 PMID:24707119 PMID:26968431 PMID:33839235 PMID:35811015 PMID:8702551
IL1Aincreases secretionEXP 6480464CTDLipopolysaccharides results in increased secretion of IL1A proteinPMID:20005085 PMID:32800949
IL1Amultiple interactionsEXP 6480464CTD15-deoxyprostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein]; [Ethanol co-treated with Lipopolysaccharides] results in decreased expression of IL1A mRNA; [Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1A mRNA; [Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL1A protein; [Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of IL1A mRNA; [Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL1A mRNA; [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IL1A protein; [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of IL1A mRNA; [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of IL1A mRNA; acanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in decreased expression of IL1A mRNA]; Flufenamic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein]; HNRNPD protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]; Phloretin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein]; Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein]; S-(1,2-dichlorovinyl)cysteine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]; Silver promotes the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]; Silybin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein]; Silymarin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein]PMID:10866999 PMID:15779068 PMID:17929310 PMID:18437699 PMID:21135123 PMID:21878375 PMID:22777745 PMID:24707119 PMID:26968431 PMID:28964808 PMID:33839235 PMID:35811015 PMID:9122163
IL1Aaffects secretionISOIl1a (Mus musculus)6480464CTDLipopolysaccharides affects the secretion of IL1A proteinPMID:30301768
IL1Aincreases cleavageISOIl1a (Mus musculus)6480464CTDLipopolysaccharides results in increased cleavage of IL1A proteinPMID:1868253
IL1Aincreases expressionISOIl1a (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of IL1A mRNA; Lipopolysaccharides results in increased expression of IL1A proteinPMID:15371095 PMID:16002565 PMID:16009389 PMID:16880258 PMID:1868253 PMID:19133137 PMID:20423518 PMID:21461237 PMID:21873422 PMID:22169119 PMID:22185406 PMID:23107598 PMID:25890327 PMID:26068648 PMID:26363317 PMID:26582142 PMID:27339419 PMID:27568862 PMID:29906493 PMID:9085146
IL1Aincreases expressionISOIl1a (Rattus norvegicus)6480464CTDLipopolysaccharides results in increased expression of IL1A proteinPMID:21362633
IL1Aincreases secretionISOIl1a (Mus musculus)6480464CTDLipopolysaccharides results in increased secretion of IL1A proteinPMID:26582142 PMID:32800949
IL1Aincreases secretionISOIl1a (Rattus norvegicus)6480464CTDLipopolysaccharides results in increased secretion of IL1A proteinPMID:21127968 PMID:21504754
IL1Amultiple interactionsISOIl1a (Mus musculus)6480464CTD(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]; (+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1A protein]; (N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1A protein]; (N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) inhibits the reaction [Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein]]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1A protein; [RORA protein affects the susceptibility to Lipopolysaccharides] which affects the expression of IL1A; Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein]; ATG5 protein affects the reaction [MJN110 affects the reaction [Lipopolysaccharides affects the secretion of IL1A protein]]; Benzene inhibits the reaction [Lipopolysaccharides results in increased cleavage of IL1A protein]; Cadmium inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]; coagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein]; Dexamethasone inhibits the reaction [IL1A protein promotes the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein]; DUSP1 gene mutant form inhibits the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]]; hydroquinone inhibits the reaction [Lipopolysaccharides results in increased cleavage of IL1A protein]; IL1A protein promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; IL6 protein affects the reaction [Lipopolysaccharides results in increased secretion of IL1A protein]; Indirubin E804 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]; Indomethacin inhibits the reaction [Benzene inhibits the reaction [Lipopolysaccharides results in increased cleavage of IL1A protein]]; Lipopolysaccharides inhibits the reaction [Indirubin E804 results in increased expression of IL1A mRNA]; Lipopolysaccharides promotes the reaction [deoxynivalenol results in increased expression of IL1A mRNA]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]; methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]; MGLL protein affects the reaction [Lipopolysaccharides affects the secretion of IL1A protein]; MJN110 affects the reaction [Lipopolysaccharides affects the secretion of IL1A protein]; phenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]; Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]; ridaifen-B inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein]; terameprocol affects the reaction [Lipopolysaccharides results in increased expression of IL1A protein]PMID:15804595 PMID:15933225 PMID:16009389 PMID:16880258 PMID:1868253 PMID:19133137 PMID:20423518 PMID:21461237 PMID:22185406 PMID:23107598 PMID:25890327 PMID:26068648 PMID:26363317 PMID:26582142 PMID:27568862 PMID:28698385 PMID:29906493 PMID:30301768 PMID:7540993
IL1Amultiple interactionsISOIl1a (Rattus norvegicus)6480464CTD2,3-bis(4-hydroxyphenyl)-propionitrile inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1A protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1A protein]; [Asbestos, Crocidolite co-treated with Lipopolysaccharides] results in increased expression of IL1A mRNA; [Asbestos, Serpentine co-treated with Lipopolysaccharides] results in increased expression of IL1A mRNA; [Glycolipids analog co-treated with Lipopolysaccharides] results in increased expression of IL1A mRNA; [potassium octatitanate co-treated with Lipopolysaccharides] results in increased expression of IL1A mRNA; [RCF-1 fiber co-treated with Lipopolysaccharides] results in increased expression of IL1A mRNA; Estradiol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1A protein]; Lipopolysaccharides promotes the reaction [Zymosan results in increased expression of IL1A protein]PMID:16192389 PMID:16374148 PMID:21127968 PMID:9400719
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