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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734192
Species: Mus musculus
RGD Object: Gene
Symbol: Gpt
Name: glutamic pyruvic transaminase, soluble
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gptincreases activityEXP 6480464CTDLipopolysaccharides results in increased activity of GPT proteinPMID:31499194
Gptincreases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of GPT proteinPMID:33038329 PMID:37177863
Gptmultiple interactionsEXP 6480464CTD3-(4-chlorophenylselanyl)-1-methyl-1H-indole inhibits the reaction [Lipopolysaccharides results in increased expression of GPT protein]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of GPT protein]; [Galactosamine co-treated with Lipopolysaccharides] promotes the reaction [idelalisib results in increased expression of ALT protein]; [Galactosamine co-treated with Lipopolysaccharides] promotes the reaction [Miransertib results in increased expression of ALT protein]; [IL10 protein co-treated with TLR4 protein] affects the reaction [Lipopolysaccharides results in increased expression of GPT protein]; [Lipopolysaccharides co-treated with Galactosamine] results in increased activity of GPT protein; [Lipopolysaccharides co-treated with Galactosamine] results in increased expression of GPT protein; [Lipopolysaccharides co-treated with Galactose] results in increased expression of GPT protein; [TLR4 protein co-treated with TNFRSF1A protein] affects the reaction [IL10 protein inhibits the reaction [Lipopolysaccharides results in increased expression of GPT protein]]; [TLR4 protein co-treated with TNFRSF1A protein] affects the reaction [Lipopolysaccharides results in increased expression of GPT protein]; [triptolide co-treated with Lipopolysaccharides] results in increased expression of GPT protein; Acetylcysteine inhibits the reaction [Lipopolysaccharides promotes the reaction [PTEN gene mutant form results in increased secretion of GPT protein]]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of GPT protein]; Dexamethasone promotes the reaction [IL10 protein inhibits the reaction [Lipopolysaccharides results in increased expression of GPT protein]]; Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased activity of GPT protein]; IL10 protein inhibits the reaction [Lipopolysaccharides results in increased expression of GPT protein]; Lipopolysaccharides promotes the reaction [PTEN gene mutant form results in increased secretion of GPT protein]; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in increased expression of GPT protein]; Plant Extracts inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of GPT protein]; RNF31 protein affects the reaction [[Lipopolysaccharides co-treated with Galactose] results in increased expression of GPT protein]; S-allylcysteine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of GPT protein]; Silymarin inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of GPT protein]; Sirolimus inhibits the reaction [Ethylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased activity of GPT protein]]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of GPT protein]; TNFRSF1A protein affects the reaction [IL10 protein inhibits the reaction [Lipopolysaccharides results in increased expression of GPT protein]]PMID:19153979 PMID:27022031 PMID:30236599 PMID:31445927 PMID:31499194 PMID:32453893 PMID:33038329 PMID:34416243 PMID:36328986 PMID:37177863
Gptincreases activityISOGpt (Rattus norvegicus)6480464CTDLipopolysaccharides results in increased activity of GPT proteinPMID:27224288
Gptmultiple interactionsISOGpt (Rattus norvegicus)6480464CTD17-(dimethylaminoethylamino)-17-demethoxygeldanamycin inhibits the reaction [Lipopolysaccharides results in increased activity of GPT protein]; 4-phenylbutyric acid inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased activity of GPT protein]; [Ethanol co-treated with Lipopolysaccharides] results in increased expression of GPT protein; [Lipopolysaccharides co-treated with Galactosamine] results in increased activity of GPT protein; [Lipopolysaccharides co-treated with Isoniazid] results in increased activity of GPT protein; pioglitazone inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of GPT protein]; Quercetin inhibits the reaction [17-(dimethylaminoethylamino)-17-demethoxygeldanamycin inhibits the reaction [Lipopolysaccharides results in increased activity of GPT protein]]PMID:15318101 PMID:25331106 PMID:27224288 PMID:28844859
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