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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69474
Species: Mus musculus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srebf1affects localizationEXP 6480464CTDLipopolysaccharides affects the localization of SREBF1 proteinPMID:21689150
Srebf1decreases expressionEXP 6480464CTDLipopolysaccharides results in decreased expression of SREBF1 mRNAPMID:16847310
Srebf1multiple interactionsEXP 6480464CTDMelatonin inhibits the reaction [Lipopolysaccharides affects the localization of SREBF1 protein]PMID:21689150
Srebf1increases expressionISOSREBF1 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of SREBF1 mRNA; Lipopolysaccharides results in increased expression of SREBF1 proteinPMID:29751049 PMID:33677747
Srebf1multiple interactionsISOSREBF1 (Homo sapiens)6480464CTD[NAT10 protein affects the susceptibility to Lipopolysaccharides] which affects the expression of SREBF1 mRNA; Butyric Acid inhibits the reaction [Lipopolysaccharides results in increased expression of SREBF1 mRNA]PMID:29751049 PMID:35877022
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