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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin-dependent kinase inhibitor 1A
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1aincreases expressionISOCdkn1a (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of CDKN1A mRNAPMID:16977382 PMID:18550754 PMID:27339419
Cdkn1amultiple interactionsISOCdkn1a (Mus musculus)6480464CTDEstradiol promotes the reaction [Lipopolysaccharides results in increased expression of CDKN1A mRNA]; Lipopolysaccharides inhibits the reaction [Indirubin E804 results in decreased expression of CDKN1A mRNA]PMID:16977382 PMID:23107598
Cdkn1amultiple interactionsISOCDKN1A (Homo sapiens)6480464CTD[NAT10 protein affects the susceptibility to Lipopolysaccharides] which affects the expression of CDKN1A mRNAPMID:35877022
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