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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621087
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Socs3
Name: suppressor of cytokine signaling 3
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Socs3increases expressionISOSOCS3 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of SOCS3 mRNAPMID:18192897 PMID:18453621 PMID:25725100 PMID:35811015
Socs3increases expressionISOSocs3 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of SOCS3 mRNAPMID:22024136 PMID:22169119 PMID:22185406 PMID:25890327 PMID:26918785 PMID:27339419
Socs3multiple interactionsISOSOCS3 (Homo sapiens)6480464CTD(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA]; [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of SOCS3 mRNA; S-(1,2-dichlorovinyl)cysteine inhibits the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA]PMID:25725100 PMID:35811015
Socs3multiple interactionsISOSocs3 (Mus musculus)6480464CTD(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA]; [Resveratrol co-treated with Lipopolysaccharides] results in increased expression of SOCS3 protein; bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA]; Eicosapentaenoic Acid promotes the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA]; IL10 protein affects the reaction [[Resveratrol co-treated with Lipopolysaccharides] results in increased expression of SOCS3 protein]; IL10 protein promotes the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA]; Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA]; tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA]PMID:22024136 PMID:22169119 PMID:22185406 PMID:25576658 PMID:25890327 PMID:26918785
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