GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3764
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sstr4
Name: somatostatin receptor 4
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases response to substanceISORGD:7355516480464CTDSSTR4 results in decreased susceptibility to Lipopolysaccharides

PMID:19622729
multiple interactionsISORGD:7355516480464CTDSSTR4 gene mutant form promotes the reaction [Lipopolysaccharides results in increased expression of IFNG protein]

SSTR4 gene mutant form promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]

PMID:19622729
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.